Association of preterm birth with IFN-gamma, IL-10, and CYP 1A1 gene in Korean women.

You, Si Yeon; Kim, Jung Myung; Lee, Kyung A; Park, Mi Hye; Kim, Young Ju; Chun, Sun Hee

doi:2010.53.7.608

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Original Article

Korean Journal of Obstetrics & Gynecology 2010;53(7):608-615.
DOI: https://doi.org/10.5468/kjog.2010.53.7.608 Published online July 1, 2010.

Association of preterm birth with IFN-gamma, IL-10, and CYP 1A1 gene in Korean women.

Si Yeon You, Jung Myung Kim, Kyung A Lee, Mi Hye Park, Young Ju Kim, Sun Hee Chun

Department of Obstetrics and Gynecology, Ewha Womans University School of Medicine, Seoul, Korea. kkyj@ewha.ac.kr

Abstract

OBJECTIVE
To investigate the association between preterm birth and cytokine genes (IFN-gamma, interleukin (IL)-10) in intrauterine infection and enzyme gene (CYP1A1) in oxidative stress response. METHODS: This study involved a case-control study conducted at Ewha Womans University Hospital in Seoul, Korea. Subjects with preterm deliveries (<37 weeks of gestation) and normal controls with term deliveries (> or =37 weeks of gestation) were selected from gravidas who had undergone prenatal examinations in the hospital and were followed until infant delivery. The weight, height, and blood samples of each participants were obtained according to standard protocols. We included subjects who gave birth to a singleton infant and had a gestational age between 24 and 42 weeks. Mutiple births, stillbirths, and congenital anomalies were excluded. Finally, 164 gravidas with preterm births and 305 normal controls with term deliveries were enrolled in the present study. RESULTS: Preterm delivery group and term delivery group had significant difference in gestational age and neonatal body weight (P<0.0001). There were no statistically significant association between preterm birth and IFN-gamma, IL-10, CYP1A1 genes (P>0.05). CONCLUSION: In this study, IFN-gamma (874A/T), IL-10 (1082A/G), IL-10 (819C/T), IL-10 (592A/C) and CYP1A1 (T6235C), CYP1A1 (Ile462val [A/G]) genes had no significant association with preterm birth.

Key Words: Preterm birth, IFN-gamma, IL-10, CYP1A1 gene

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