Anti-Yo-associated paraneoplastic cerebellar degeneration in a patient with chemotherapy-responsive ovarian cancer: A case report with a review of literatures.

Song, Seung Hun; Park, Choong Hak; Park, Jin Wan

Case Report

Korean Journal of Obstetrics & Gynecology 2008;51(12):1528-1532.
Published online December 1, 2008.

Anti-Yo-associated paraneoplastic cerebellar degeneration in a patient with chemotherapy-responsive ovarian cancer: A case report with a review of literatures.

Seung Hun Song, Choong Hak Park, Jin Wan Park

Department of Obstetrics and Gynecology, College of Medicine, Dankook University, Cheonan, Korea. parkdkog@ dankook.ac.kr

Abstract

Paraneoplastic cerebellar degeneration (PCD), the one of rare paraneoplastic syndromes, refer to clinical disorders associated mostly with lung, ovarian and breast cancer, but not directly caused by cancer or its metastasis. PCD is a condition whereby the Purkinje cells of the cerebellar cortex are damaged secondary to an autoimmune process. We report here on the case of PCD of subacute onset in a patient at 7 months after surgery for ovarian cancer. Although the cases of PCD has rarely been reported, the present case appears to be the first in Korea in which PCD was associated with anti-Yo antibody in patient with chemotherapy-responsive ovarian cancer. The clinical significance of PCD associated with anti-Yo antibody is reviewed.

Key Words: Paraneoplastic cerebellar degeneration, Anti-Yo antibody, Ovarian cancer