| When should human papillomavirus (HPV) testing be done after conization?. |
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So Young Kim, Eun Seop Song, Suk Jin Choi, Keun Sung Kim, Ki Eun Lee, Seok Mo Kim, Jee Hyung Park, Sang Yong Song, Yun Seob Song |
1Department of Obstetrics and Gynecology, Inha University, Incheon, Korea. songsong2000@hotmail.com
2Department of Pathology, College of Medicine, Inha University, Incheon, Korea.
3Inha Research Institute for Medical Science, Inha University, Incheon, Korea.
4Department of Food Science and Technology, Chung-Ang University, Seoul, Korea.
5Department of Obstetrics and Gynecology, College of Medicine, Chonnam University, Gwanju, Korea.
6Department of Pathology, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea.
7Department of Urology, College of Medicine, Soonchunhyong University, Seoul, Korea. |
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| Abstract |
OBJECTIVE
To know when human papillomavirus (HPV) testing should be done after conization. METHODS: Between 1997 to 2004, Large Loop Excisions of the Transformation Zone (LLETZ) were done for conization to women with cervical pathology at A University Hospital. The Pap and HPV typing were done before LLETZ procedures. After conizations, HPV typing were planned to be done every 3 months. Every HPV typing was done by HPV oligonucleotide microarray (Biomedlab Co., Seoul, South Korea). RESULTS: For 8 years, 120 LLETZ were enrolled in this study. There were 8 cases of no neoplasm, 9 cases of CIN 1, 17 cases of CIN 2, 74 cases of CIN 3, 10 cases of microinvasive cervix cancer, and 2 cases of adenocarcinoma in situ. HPV DNA before LLETZ procedures was found about 85.0% and subtype 16 was the most common type among the patients with cervical lesion (40.8%). After LLETZ, 190 HPV typing were done through 1,307 total months (average, 6.9 months/typing). 95 (79.2%) cases had negative results, and 25 (20.8%) cases had positive results. Our data showed that, after conization, about 80% turned out to negative in 6 months. CONCLUSION: Our data suggested HPV DNA testing should be done after 6 months of LLETZ, as about 80% were destined to negative in 6 months. |
| Key Words:
LLETZ, HPV oligonucleotide microarray, HPV persistence |
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