Clinical Analysis of 23 Cases of Endometrial Stromal Sarcoma.

Park, Sang Min; Jung, Min Hyung; Lee, Jung Nam; Ma, Jin Young; Kim, Dae Yeon; Kim, Jong Hyeok; Kim, Yong Man; Kim, Young Tak; Nam, Joo Hyun; Mok, Jung Eun

Original Article

Korean Journal of Obstetrics & Gynecology 2006;49(2):374-382.
Published online February 1, 2006.

Clinical Analysis of 23 Cases of Endometrial Stromal Sarcoma.

Sang Min Park, Min Hyung Jung, Jung Nam Lee, Jin Young Ma, Dae Yeon Kim, Jong Hyeok Kim, Yong Man Kim, Young Tak Kim, Joo Hyun Nam, Jung Eun Mok

Department of Obstetrics and Gynecology, College of Medicine, University of Ulsan, Asan Medical Center, Seoul, Korea. ymkim@amc.seoul.kr

Abstract

OBJECTIVE
The aim of this retrospective study was to evaluate the survival, recurrence and prognostic factors of endometrial stromal sarcoma (ESS). METHODS: Twenty three patients who had diagnosed with ESS and managed between June 1989 and December 2004 were included. Clinicopathologic characteristics were evaluated including age, parity, menopause, stage, grade, type of surgery, adjuvant therapy, overall survival, disease free survival. RESULTS: The mean age of the group was 44 years. Eighty two percents of patients were premenopause and the most common symptom was vaginal bleeding. Thirteen patients were in stage I and four patients were in stage II and III. Six patients were not able to determine the stage. Eighteen patients were low grade ESS and five patients were high grade. The median overall survival was 179 months and the median disease free survival was 134 months. Disease had recurred in 6 patients and 2 patients died of the disease. Higher tumor grade was associated with lower overall survival (P=0.047) and disease free survival (P=0.035). CONCLUSION: The prognostic factor of ESS is tumor grade.

Key Words: Endometrial stromal sarcoma, Uterine sarcoma