Identification of High Risk Group of HPV associated with Cervical Cancer in Korean Women.

Lee, Byung Kwan; Lee, Bang Hyun; Yoon, Hyo Jin; Lee, Sang Hee; Park, Min Hye; Kwon, Hyuck Chan; Lim, Jung Ae

Original Article

Korean Journal of Obstetrics & Gynecology 2004;47(12):2366-2372.
Published online December 1, 2004.

Identification of High Risk Group of HPV associated with Cervical Cancer in Korean Women.

Byung Kwan Lee, Bang Hyun Lee, Hyo Jin Yoon, Sang Hee Lee, Min Hye Park, Hyuck Chan Kwon, Jung Ae Lim

¹Department of Obstetrics and Gynecology, Major Women's Care Center, Seoul, Korea.
²Medical Laboratory Center, Major Women's Care Center, Seoul, Korea.

Abstract

OBJECTIVE
To identify genital HPV types and high risk group of HPV associated with cervical cancer in Korean women. METHODS: Both Pap test and HPV-DNA test using PCR assay were performed as screening test for cervical cancer in this clinic. When patients were positive in HPV-DNA test, HPV genotyping using sequencing method and cervical biopsy were performed. RESULTS: Frequent age group of HPV infection was 40 yrs (34.3%) and prevalence of HPV infection was 9.8%. Twenty-three types of HPV were detected. HPV 16 and 58 were detected in invasive cancer. HPV 16, 31, 33, 45, and 58 were detected in HSIL. HPV 6, 11, 18, 53, 59, and 66 were detected in LSIL. HPV 16 was most commonly detected in HSIL and invasive cancer. CONCLUSION: HPV 16, 31, 33, 45, and 58 are included in high risk group of HPV in Korean women. It may be very effective in early detection of cervical cancer to classify HPV types included in high risk group of cervical cancer in Korean women and to perform cervical biopsy in the patients who have high risk types of HPV infection.

Key Words: HPV-DNA test, HPV-genotyping, High risk group of HPV