The Study about the change of Fetal Adrenal Gland Hormone during Pregnancy and Labor.

Cho, Hye Jin; Lim, Ju Seong; Choi, Sang Joon; Song, Chang Hun; Kim, Kweon Young

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Original Article

Korean Journal of Obstetrics & Gynecology 2004;47(11):2064-2069.
Published online November 1, 2004.

The Study about the change of Fetal Adrenal Gland Hormone during Pregnancy and Labor.

Hye Jin Cho, Ju Seong Lim, Sang Joon Choi, Chang Hun Song, Kweon Young Kim

¹Department of Obstetrics and Gynecology, College of Medicine, Chosun University, Gwang-Ju, Korea.
²Department of Physical Medicine and Rehabilitation, College of Medicine, Chosun University, Gwang-Ju, Korea.

Abstract

OBJECTIVE
Fetal adrenal gland hormone was known to have close association with fetal weight and labor pain in response to fetal stress. Our purpose was to analyze the correlation between cortisol, DHEA-S in cord blood and obstetric status of fetuses. METHODS: We collected cord blood samples from 60 neonates immediately after delivery of baby. Six cases were complicated by intrauterine growth restriction and fourteen patients were complicated by preeclampsia. We measured cortisol, DHEA-S levels by using the RIA commercial Kits for the ELISA. We performed statistic analysis of the data on the SPSS computer program. RESULTS: Cortisol was significantly higher in intrauterine growth restriction (23.4 +/- 16.2 microgram/dL) statistically than control group (13.7 +/- 9.5 microgram/dL) (P=0.022). Cortisol and DHEA-S had negative correlation each other (P=0.025). DHEA-S was significantly lower in intrauterine growth restriction (1202.2 +/- 1005.9 ng/ mL) than control group (1714.8 +/- 978.6 ng/mL) (P=0.01). DHEA-S had increased with advancing gestational age (P=0.03) and fetal weight (P=0). CONCLUSION: Cord blood cortisol level and DHEA-S level has close association with intrauterine growth restriction and negative correlation with each other.

Key Words: Cord blood, Cortisol, DHEA-S

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