Effects of Isoflavone on Surgically Menopaused Women.

Jo, Hyun Hee; Kim, Mee Ran; Kwon, Dong Jin; Kim, Jang Heub; Lew, Young Ok; Kim, Jin Hong

Randomized Controlled Trial

Korean Journal of Obstetrics & Gynecology 2004;47(6):1223-1227.
Published online June 1, 2004.

Effects of Isoflavone on Surgically Menopaused Women.

Hyun Hee Jo, Mee Ran Kim, Dong Jin Kwon, Jang Heub Kim, Young Ok Lew, Jin Hong Kim

Department of Obstetrics and Gynecology, Catholic University Medical College, Seoul, Korea.

Abstract

OBJECTIVE
To evaluate the effects of isoflavone intake on estrogen deprivated symptoms in surgically menopaused women. METHODS: Premenopausal women who took total hysterectomy with both adnexectomy were randomized into three groups. One group took conjugated equine estrogen 0.625 mg daily for 12 weeks after surgery, the second group took isoflavone 100 mg #3 daily for 12 weeks after surgery, and the third group took no medication for controlled group. Questionnaires about the acute menopausal symptoms, incontinence score, blood lipid profile, bone turnover marker were checked before and 12 weeks after surgery. RESULTS: Kupperman's index and insentience score were showed less increased rate than control group. Total cholesterol and triglyceride were increased in all groups and HDL cholesterol was increased in estrogen and isoflavone groups. Osteocalcin was decreased in estrogen and isoflavone groups, ICTP was decreased in estrogen group, and increased in the other groups. CONCLUSION: Isoflavone was effective to acute postmenopusal symptoms, urogenital atrophy and bone turnover.

Key Words: Isoflavone, Kupperman's index, Incontinence, Bone turenover marker