An Unusual Relapse of Acute Lymphoblastic Leukemia in the Uterine Corpus.

Kwon, Ji Young; Song, Min Jong; Choi, Woon Min; Lee, Young; Rha, Jong Gu; Kim, Soo Pyung

Case Report

Korean Journal of Obstetrics & Gynecology 2003;46(9):1781-1784.
Published online September 1, 2003.

An Unusual Relapse of Acute Lymphoblastic Leukemia in the Uterine Corpus.

Ji Young Kwon, Min Jong Song, Woon Min Choi, Young Lee, Jong Gu Rha, Soo Pyung Kim

Department of Obstetrics and Gynecology, College of Medicine, The Catholic University of Korea, Seoul, Korea.

Abstract

The relapse of leukemia is usually classified as hematologic relapse and extramedullary relapse. The most common sites of clinical extramedullary relapse are the central nervous systems (CNS) and gonads. However, the relapse in the uterus is very rare. We experienced a very unusual case of uterine relapse of acute lymphoblastic leukemia (ALL) after about a 6-year remission period. This female patient returned to our hospital with a two-month history of amenorrhea. Pelvic radiology confirmed an about 7 cm sized ill-defined ovoid mass in the uterus. There was no evidence of ALL relapse in the peripheral blood or CNS. The uterine biopsy showed diffused homogenous infiltration of numerous small round cells in uterine corpus, suggesting ALL relapse. The bone marrow study revealed 100% cellularity, most of which were lymphoblasts. Our patient received the bone marrow transplantation (BMT) and achieved the second complete remission (CR). Therefore, we here report our case with a brief review of literature.

Key Words: Acute lymphoblastic leukemia, Relapse, Uterine corpus