Cytogenetic Aberration Analysis of Midtrimester Amniotic Fluid.

Kim, Gwang Jun; Choi, Su Ran; Kim, Suk Young; Yoon, Sung Jun; Han, Eun Hye; Ahn, Jung Rerl; Choi, Yu Duk; Lee, Soon Pyeu; Whang, Byung Chul; Lee, Eyi Don; Choi, Seung Hyun

Original Article

Korean Journal of Obstetrics & Gynecology 2002;45(6):1040-1044.
Published online June 1, 2002.

Cytogenetic Aberration Analysis of Midtrimester Amniotic Fluid.

Gwang Jun Kim, Su Ran Choi, Suk Young Kim, Sung Jun Yoon, Eun Hye Han, Jung Rerl Ahn, Yu Duk Choi, Soon Pyeu Lee, Byung Chul Whang, Eyi Don Lee, Seung Hyun Choi

¹Department of Obstertics and Gynecology of Gachon Medical College, Incheon.
²Department of clinical pathology of Gachon Medical College, Incheon.

Abstract

OBJECTIVE
To analyze cytogenetic results of prenatal genetic amniocentesis. METHODS: From January 1997 to December 2000, We analyzed 1,390 cases of midtrimester amniocentesis which were done at Gil medical center of Gachon medical school according to its indications and maternal age. RESULTS: Chromosomal aberrations were found in 88 cases (6.3%). Of all our chromosomal aberrations, 29 cases (2.1%) of normal variants and 59 cases (4.2%) of abnormal karyotypes were found. 37 cases of autosomal numerical abnormal karyotypes and 7 cases of sex chromosomal abnormal karyotypes were diagnosed. In abnormal karyotype group, the incidence was high after 40 years of maternal age and in abnormal ultrasound findings, but no such correlations were found in normal variant group. CONCLUSION: In analysis of midtrimester amniocentesis, it would be better to analyze separately abnormal karyotype group and normal variant group.

Key Words: Midtrimester amniocentesis, Chromosomal abnormality, normal variant