Changes of Biochemical Markers of Bone turnover in Pre-, Peri-and Postmenopausal Women.

Yang, Yun Seok; Nam, Gi Nam; Park, Jun Sook

Original Article

Korean Journal of Obstetrics & Gynecology 2000;43(5):819-829.
Published online January 1, 2001.

Changes of Biochemical Markers of Bone turnover in Pre-, Peri-and Postmenopausal Women.

Yun Seok Yang, Gi Nam Nam, Jun Sook Park

Abstract

OBJECTIVE
This study investigated changes of Biochemical Markers of Bone turnover in Pre-, Peri-and Postmenopausal Women METHOD: The levels of Urinary deoxypyridinoline(Dpd), serum total alkaline phosphatase(TALP), osteocalcin(OC), serum calcium(Ca++) and phosphorus(P) were determined. Bone mineral density(BMD) were also measured by dual energy X-ray absorptiometry (DEXA) RESULTS: There were negative correlation between Biochemical markers of bone turnover and BMD, Biochemical markers of bone turnover in osteoporosis group were significantly higher than normal groups. Biochemical marker of bone turnover except serum calcium increased after menopause and remains elevated in late postmenopausal and elderly women. An increased bone turnover rate to sustained serum calcium in constant level is related to a high rate of bone loss in postmenopausal women and to a decreased bone mass in elderly women. CONCLUSION: Bone turnover increased not only at the time of menopause but also in the elderly women. This subsequent abnormalities of bone resorption and formation in the elderly women suggest their potential role in osteoporosis.

Key Words: Bone turnover markers, Osteoporosis, Menopause