Comparison of Early and Mid-Second-Trimester Amniocentesis.

Ann, Hyun Kyong; Ryu, Hyun Mee; Kim, Moon Young; Kim, En Sung; Song, Ha Kyun; Lee, Hwan Kyoun; Han, Jung Ryeol; Kim, Jin Mee; Choi, Soo Kyung; Han, Ho Won

Original Article

Korean Journal of Obstetrics & Gynecology 1997;40(1):123-128.
Published online January 1, 2001.

Comparison of Early and Mid-Second-Trimester Amniocentesis.

Hyun Kyong Ann, Hyun Mee Ryu, Moon Young Kim, En Sung Kim, Ha Kyun Song, Hwan Kyoun Lee, Jung Ryeol Han, Jin Mee Kim, Soo Kyung Choi, Ho Won Han

Abstract

We sought to determine whether early amniocentesis is a safe and acceptable method of genetic evaluation in early pregnancy. During the 20-month period from February 1994 to September 1995, 80 consecutive early amniocentesis were performed transabdominally at 12(+3)-14(+6) weeks of gestation and 305 consecutive mid-second-trimester transabdominal amniocenteses were performed at 16(+0)-18(+0) weeks of gestation. All amniotic fluid samples were cultured using flask method. There were no significant differences between the early and mid-second-trimester amniocenteses in failed sampling, ambiguous results, pregnancy loss within 4 weeks after the procedure, pregnancy loss from 4 weeks after procedure to 28 weeks of gestation, preterm birth, and perinatal death. We may conclude that early amniocentesis is a safe and acceptable method for prenatal diagnosis.

Key Words: Early amniocentesis, Genetic evaluation