Concentration of cord serum adiponectin in normal and gestational diabetic pregnancies.

Cho, Ah Ra; Kim, Young Ju; Chun, Sun Hee; Cho, Su Jin; Park, Eun Ae; Park, Mi Hye

doi:2011.54.9.485

Obstet Gynecol Sci > Volume 54(9); 2011 > Article

Original Article

Korean Journal of Obstetrics & Gynecology 2011;54(9):485-491.
DOI: https://doi.org/10.5468/KJOG.2011.54.9.485 Published online September 1, 2011.

Concentration of cord serum adiponectin in normal and gestational diabetic pregnancies.

Ah Ra Cho, Young Ju Kim, Sun Hee Chun, Su Jin Cho, Eun Ae Park, Mi Hye Park

¹Department of Obstetrics and Gynecology, Ewha Womans University School of Medicine, Seoul, Korea. ewhapmh@ewha.ac.kr
²Department of Pediatrics, Ewha Womans University School of Medicine, Seoul, Korea.

Abstract

OBJECTIVE
To investigate the effect of intrauterine environment on adiponectin level in cord blood through comparison of normal pregnancy group and gestational diabetes group. METHODS: This cross sectional study included women with: normal pregnancy (n = 204); and patients with gestational diabetes mellitus (GDM) (n = 204). Among GDM patients, 118 were managed with diet alone and 86 were insulin requiring. Cord serum adiponectin concentration at birth was measured by enzyme-linked immunosorbent assay. RESULTS: Cord serum adiponectin concentration was higher in GDM treatment pregnancies compared with normal pregnancies (P = 0.02). Cord serum adiponectin concentration was higher in female compared with male fetuses both normal and gestational diabetes pregnancies (P = 0.04, P = 0.03). In normal pregnancies, cord serum adiponectin concentration was positively correlated with gestational age (r = 0.2374, P < 0.02). In normal pregnancies, cord serum adiponectin concentration did not correlated with birth weight (r = -0.05, P > 0.05). Cord serum adiponectin concentration was not different between only diet treated women and insulin requiring women in GDM (P > 0.05). CONCLUSION: Sex dimorphism for adiponectin and the change of adiponectin in GDM offsprings, first appear in utero. Higher adiponectin levels in females or GDM offsprings reflect increased adiposity of the fetuses.

Key Words: Cord serum adiponectin, Gestational diabetes mellitus, Sex characteristics, Adiposity