| Maternal serum levels of C-reactive protein and placental levels of IL-6, lipid peroxide, and protein carbonyl in preterm birth according to histologic chorioamnionitis. |
|
Dae Seok Yoon, Yoon Ha Kim, Chul Hong Kim, Moon Kyoung Cho, Jong Woon Kim, Hye Yon Cho, Seok Mo Kim, Woo Dae Kang, Ki Ho Lee, Tae Bok Song |
1Department of Obstetrics and Gynecology, Chonnam National University Medical School, Gwangju, Korea. kimyh@chonnam.ac.kr
2Department of Obstetrics and Gynecology, Seonam University College of Medicine, Namwon, Korea. |
|
|
| Abstract |
OBJECTIVE
To evaluate predictive value of maternal serum white blood cells (WBCs), C-reactive protein (CRP) levels, placental interleukin-6 (IL-6), lipid peroxide, and protein carbonyl levels in preterm birth according to histologic chorioamnionitis (HCA). METHODS: This cohort study included 45 cases of preterm delivery with preterm labor and intact membranes (preterm labor [PTL] group; n=16) and preterm premature rupture of membranes (preterm premature rupture of membranes [PPROM] group; n=29). Blood samples at admission and placental sample at postpartum were collected. HCA was diagnosed in the presence of neutrophils infiltration into the subamnionic space. RESULTS: The incidence of HCA was significantly higher in PPROM group than PTL group. Maternal serum WBC and CRP levels at admission, and placental IL-6, lipid peroxide, and protein carbonyl levels in HCA group were significantly higher than group without HCA. Maternal serum CRP levels at admission, and placental IL-6, lipid peroxide, and protein carbonyl levels of PPROM group with HCA were significantly higher than PPROM group without HCA. Maternal serum CRP levels at admission of 7 days and more latency period (n=14) were significantly lowered than those of less than 7 days latency period (n=15). The cut-off points of CRP determined with the receiver operating characteristic curves was 0.875 mg/dL. Perinatal morbidity such as respiratory distress syndrome, intraventricular hemorrhage, pneumonia in HCA group was significantly higher than group without HCA. CONCLUSION: Maternal serum CRP on admission may be possible a predictor for duration of the latency period in PPROM. |
| Key Words:
Preterm birth, Histologic chorioamnionitis, C-reactive protein, Lipid peroxides, Protein carbonyls |
|
PDF Links
Full text via DOI
Download Citation
