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Obstet Gynecol Sci > Volume 53(7); 2010 > Article
Korean Journal of Obstetrics & Gynecology 2010;53(7):626-632.
DOI: https://doi.org/10.5468/kjog.2010.53.7.626    Published online July 1, 2010.
Clinical characteristics of women with Mullerian anomaly: Twenty years of experience at Asan Medical Center.
Gyun Ho Jeon, Yu Ran Park, You Jung Shin, Sung Hoon Kim, Hee Dong Chae, Chung Hoon Kim, Byung Moon Kang
1Department of Obstetrics and Gynecology, Asan Medical Center, Ulsan University College of Medicine, Seoul, Korea. hdchae@amc.seoul.kr
2Department of Obstetrics and Gynecology, Inje University College of Medicine, Haeundae Paik Hospital, Busan, Korea.
Abstract
OBJECTIVE
To investigate the clinical characteristics and reproductive outcomes of women with Mullerian anomalies. METHODS: One hundred and eighty-six patients were diagnosed with Mullerian anomalies at the Asan Medical Center from 1990 to 2009 and their clinical characteristics and reproductive outcomes were analyzed. Mullerian anomalies were categorized according to the classification by the American Fertility Society (1988). RESULTS: Mullerian anomaly was noticed in 1 in 1,326 patients (0.075%). Most cases were found in adulthood (84.9%) whereas only 15.1% cases in adolescent or pediatric period. More than 40% of cases were asymptomatic and found incidentally but others suffered from amenorrhea (12.4%), dysmenorrhea (10.8%), abnormal menstruation (10.2%), etc. Most common type of uterine anomalies was uterine didelphys (30.6%), followed by bicornuate uterus (19.4%), Mayer-Rokitansky-Kuster-Hauser syndrome (10.8%), septate uterus (9.1%) and unicornuate uterus (8.6%). On the reproductive outcomes of 251 pregnancies identified, spontaneous miscarriages and preterm labor were quite common (55.8%), and the overall live birth rate was 48.6%. When each anomaly was individually analyzed, the live birth rate was 60.0% in the arcuate uterus and 58.0% in the uterine didelphys. The unicornuate and bicornuate uterus presented a similar chance of having a living child (42.1%, 46.7%), while the septate uterus showed a relatively lower live birth rate (32.4%). CONCLUSION: Although most cases of Mullerian anomalies are diagnosed in adulthood, many patients may suffer from menstrual abnormalities, dysmenorrhea or recurrent miscarriages since adolescence. The reproductive outcomes of the arcuate uterus and uterine didelphys were better, while those of septate uterus were poor in our study.
Key Words: Clinical characteristics, Reproductive outcomes, Mullerian anomalies, Live birth rate, Uterine anomalies


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