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Obstet Gynecol Sci > Volume 53(7); 2010 > Article
Korean Journal of Obstetrics & Gynecology 2010;53(7):616-625.
DOI: https://doi.org/10.5468/kjog.2010.53.7.616    Published online July 1, 2010.
Inhibition of cell growth and apoptosis in CaSki, cervical cancer cell line by arsenic compounds.
Jung Mi Byun, Dae Hoon Jeong, Dae Sim Lee, Joo Ran Kim, Young Nam Kim, Eun Jeong Jeong, Moon Su Sung, Kyoung Bok Lee, Ki Tae Kim
1Department of Obstetrics and Gynecology, Inje University College of Medicine, Busan Paik Hospital, Busan, Korea. buzzmi@chol.com
2Paik Institute for Clinical Research, Inje University College of Medicine, Busan Paik Hospital, Busan, Korea.
Abstract
OBJECTIVE
To compare inhibition of cell growth and apoptosis in human cervical cancer cell lines (CaSki) by paclitaxel, cisplatin, arsenic trioxide and tetraarsenic oxide. METHODS: Inhibition of cell growth was determined by the water-soluble tetrazolium salts (WSTs) -1 assay. For apoptosis analysis in CaSki cell line treated with single or combination of two agents, CaSki cell line treated with each agent was stained with annexin-V/PI and flow cytometry was performed. RESULTS: Progression of apoptosis in CaSki cell line treated with paclitaxel, cisplatin, arsenic trioxide, and tetraarsenic oxide was time dependent. Inhibition of cell growth in CaSki cell line by paclitaxel, cisplatin, arsenic trioxide, and tetraarsenic oxide was dose and time dependent. Especially, tetraarsenic oxide was more effective in inhibition of CaSki cell growth compared to arsenic trioxide. Group treated with combination of cisplatin and tetraarsenic oxide showed more progressive apoptosis compared to other combination group. CONCLUSION: Tetraarsenic oxide has more potent anti-tumor effects than other agents on CaSki cell line. We need to consider further study about antitumor effect of tetraarsenic oxide through clinical study.
Key Words: Cervical cancer, Paclitaxel, Cisplatin, Arsenic trioxide, Tetraarsenic oxide, Apoptosis


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