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Korean Journal of Obstetrics & Gynecology 2009;52(11):1164-1168.
Published online November 1, 2009.
One case of Lynch type II syndrome.
Kyongjin Kim, Nam Eui Kim, Yongho Lee, Kyounga Kim, Sangki Hong, Sukyung Baek, Myungjin Joo
1Department of Obstetrics and Gynecology, Presbyterian Medical center, Jeon-ju, Korea. kyungjin_k@hotmail.com
2Department of pathology, Presbyterian Medical center, Jeon-ju, Korea.
Abstract
Lynch syndrome is also called Hereditary nonpolyposis colorectal cancer (HNPCC). It is characterized by a risk of colorectal cancer and other cancers of the endometrium, ovary, stomach, small intestine etc. The increased risk is due to inherited mutations that impaired DNA mismatch repair. Two to three percentage of colon cancer is caused by Lynch syndrome. A family history of colon cancer occurs at a young age. We experienced one case of Lynch syndrome who had had stomach cancer, endometrial cancer and colon cancer recently. Hence we report this case with a brief review of literature.
Key Words: Endometrial cancer, HNPCC, Colorectal cancer, MSI (microsatellite instability), MMR (mismatch repair)


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