A case of microinvasive Paget's disease of the vulva: Treatment of positive resection margin with topical 5-FU cream application.

Kang, Ho Jeong; Park, Chul Min; Shim, Soon Sup; Son, Young Soo; Kim, Sung Yob

Case Report

Korean Journal of Obstetrics & Gynecology 2009;52(3):372-376.
Published online March 1, 2009.

A case of microinvasive Paget's disease of the vulva: Treatment of positive resection margin with topical 5-FU cream application.

Ho Jeong Kang, Chul Min Park, Soon Sup Shim, Young Soo Son, Sung Yob Kim

Department of Obstetrics and Gynecology, Cheju National University, College of Medicine, Jeju, Korea. kimsy@cheju.ac.kr

Abstract

Extramammary Paget's disease of the vulva is a rare lesion that accounts for 1~2% of vulvar neoplasms. Paget's disease often has a microscopic extension beyond the gross lesion and shows a multifocal distribution. Positive resection margin is common. We applied 5-FU cream on the lesion who had a positive resection margin. There was no residual lesion on multiple punch biopsies after 5-FU cream treatment three months later. And there has been no evidence of disease recurrence in the 12-month follow-up period. We experienced a case of effective treatment with 5-FU cream in microinvasive Paget's disease of the vulva with positive resection margin. We present it with a brief review of literatures.

Key Words: Extramammary Paget's disease of the vulva, 5-fluorouracil (5-FU)