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Korean Journal of Obstetrics & Gynecology 2008;51(7):744-749.
Published online July 1, 2008.
The clinical implications of acquired thrombophilia in patients with ovarian hyperstimulation syndrome.
Sun Min Kim, Byung Chul Jee, Jae Weon Kim, Jung Min Youn, Hyun Ui Lee, Chang Suk Suh, Seok Hyun Kim
1Department of Obstetrics and Gynecology, College of Medicine, Seoul National University, Seoul, Korea.
2Department of Obstetrics and Gynecology, Seoul National University Bundang Hospital, Seongnam, Korea. blasto@snubh.org
Abstract
OBJECTIVE
To investigate the clinical significance of thrombophilia in patients admitted with ovarian hyperstimulation syndrome (OHSS). METHODS: Twenty-five infertile women who were admitted into university hospital due to OHSS after ovarian hyperstimulation for intrauterine insemination or in vitro fertilization. Blood samples were drawn at the time of admission and three thrombophilic factors were assayed; antithrombin III, protein C and protein S. Subjects were divided into severe (n=18) and mild-to-moderate (n=7) OHSS, and laboratory parameters including three thrombophilic factors were compared. RESULTS: Antithrombin III level was abnormal in 40% of subjects, protein C in 12%, and protein S in 72%. There was no significant difference in the laboratory parameters between the patients with normal (n=15) and abnormal antithrombin III levels (n=10). However, the patients with abnormal antithrombin III levels had significantly more severe OHSS than those with normal value (100% vs 55.6%, P=0.013). The patients with at least one abnormal thrombophilic factor had significantly more severe OHSS than those with all normal value (94.4% vs 42.9%, P=0.012). CONCLUSIONS: Thrombophilic factors, particularly antithrombin III, may be associated with disease severity in patients with OHSS.
Key Words: Ovarian hyperstimulation syndrome, Thrombophilia, Antithrombin III


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