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Korean Journal of Obstetrics & Gynecology 2007;50(10):1396-1404.
Published online October 1, 2007.
Mullerian inhibiting substance as a predictive marker of menopausal transition.
Ji Sun We, Jae Yen Song, Sue Yeon Kim, Yun Sung Jo, Hyun Hee Jo, Mee Ran Kim, Jin Hong Kim, Jang Heub Kim
Department of Obstetrics and Gynecology, College of Medicine, Catholic University of Korea. janghkim@catholic.ac.kr
Abstract
OBJECTIVE
To identified whether serum Mullerian inhibiting substance (MIS) level may be used as a predictive marker of menopausal transition. METHODS: Serum MIS level was measured in reproductive women (n=87), in menopausal transition women (n=58), and in menopausal women (n=5) by ELISA. And we examined the immunohistochemical staining of the MIS in the ovarian tissues of 15 reproductive, 15 menopausal transition, and 5 menopausal women. RESULTS: 1. In the reproductive women, mean serum MIS level was 1.73+/-1.07 ng/ml. In the menopausal transition women, mean serum MIS level was 0.18+/-0.11 ng/ml. Serum MIS level did not show any significant fluctuation patterns according to follicular development. In menopausal transition women, serum MIS level was significantly lower than that of reproductive women (P<0.001). The cutoff value of serum MIS level for menopausal transition was 0.5 ng/mg. In the menopausal women, serum MIS level was not detected. 2. Serum MIS level was significantly decreased as patient age was increased. 3. In the reproductive group, the immunohistochemical staining demonstrated strong expression of MIS in the granulosa cells of the primary follicles and the growing follicles, but not in corpus luteum, preovulatory mature follicle, atretic follicle, and corpus luteum. In the menopausal transition women, immunohistochemical staining for MIS was observed in the nearly same pattern as that of thereproductive women, but with weaker expression. In the menopausal women, immunohistochemical staining of the MIS was not observed. CONCLUSION: MIS is a good candidate for predictive marker for ovarian aging and perimenopausal transition.
Key Words: Mullerian inhibiting substance, Menopausal transition, Granulosa cell, ELISA, Immunohistochemical staining


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