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Korean Journal of Obstetrics & Gynecology 2007;50(1):142-148.
Published online January 1, 2007.
The efficacy and safety of the combined preparation of Black Cohosh and St. John's wort in menopausal women.
Ho Beom Park, Yun Dan Kang, Hyun Chul Cho, Won Ki Lee, Jin Wan Park
Department of Obstetrics and Gynecology, College of Medicine, Dankook University, Cheonan, Korea. parkdkog@dankook.ac.kr
The aim of this study was to assess the efficacy and safety of the combined preparation of black cohosh and St. John's wort (GYNO-Plus(R)) in post menopausal women with symptoms. METHODS: A total number of 60 postmenopausal women with climacteric symptoms was allocated to take GYNO-Plus(R) for 3 months. And the change of the Kupperman menopausal index (KI), serum FSH and E2 level, bone densitometry (BMD), mammographic density, liver function test (LFT) and adverse effects were assessed. RESULTS: There was statistical difference in the decline of KI after 3 months treatment. But, there were no statistical differences in the change of serum FSH and E2 level, BMD, mammographic density, and LFT. There were nine adverse events in study, but two cases were directly related to the drug and they were resolved without any sequela. CONCLUSION: This study suggests that the combined preparation of black cohosh and St. John's wort is a safe, effective alternative treatment option for patients in whom hormone replacement therapy is either refused or contraindicated.
Key Words: menopause, Black cohosh, St. John's wort, efficacy, safety

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