A Case of Large Cell Neuroendocrine Carcinoma accompanied with Adenocarcinoma of the Uterine Cervix.

Kim, Yu Re; Kim, Man Gi; Kyeong, Kyu Sang; Jo, A Ra; Hong, Seung Hwa; Park, Yeon Jin; Ji, Ill Woon; Jeong, Eun Hwan; Kim, Hak Soon; Lee, Ok Jun

Case Report

Korean Journal of Obstetrics & Gynecology 2006;49(9):2004-2011.
Published online September 1, 2006.

A Case of Large Cell Neuroendocrine Carcinoma accompanied with Adenocarcinoma of the Uterine Cervix.

Yu Re Kim, Man Gi Kim, Kyu Sang Kyeong, A Ra Jo, Seung Hwa Hong, Yeon Jin Park, Ill Woon Ji, Eun Hwan Jeong, Hak Soon Kim, Ok Jun Lee

¹Department of Obstetrics and Gynecology, Chungbuk National University College of Medicine, Cheongju, Korea. hakskim@cbnu.ac.kr
²Department of Pathology, Chungbuk National University College of Medicine, Cheongju, Korea.

Abstract

Large cell neuroendocrine carcinoma of the uterine cervix is a rare and highly aggressive cervical neoplasm. Metastases and recurrences of the tumor are common. Cervical large cell neuroendocrine carcinomas are distinctive cervical carcinomas that are frequently misdiagnosed and have unfavorable prognosis. So prudential care must be considered for proper diagnosis and multimodal treatment may be required for better survival. We experienced one case of large cell neuroendocrine carcinoma accompanied with adenocarcinoma of the uterine cervix in 52 year old woman. The uterine cervix covered and infiltrated with adenocarcinoma cells and attached polypoid mass (3.2 x 2.1 cm) composed of large cell neuroendocrine carcinoma cells. The diagnosis was confirmed by immuno-staining using cytokeratin (+), synaptophysin (+), chromogranin (+), neuron-specific enolase (+), CD 56 (+), and vimentin (-). So we report the case with brief review of the literature.

Key Words: Large cell neuroendocrine carcinoma, Cervical cancer