A case of low-grade endometrial stromal sarcoma with multiple metastasis.

Cho, Han Byoul; Kim, Jae Hoon; Hong, Soon Won; Lee, Hyun Joon; Kim, Min Kyoung; Kim, Sung Hoon; Kim, Young Tae; Kim, Jae Wook

Case Report

Korean Journal of Obstetrics & Gynecology 2006;49(9):1993-1998.
Published online September 1, 2006.

A case of low-grade endometrial stromal sarcoma with multiple metastasis.

Han Byoul Cho, Jae Hoon Kim, Soon Won Hong, Hyun Joon Lee, Min Kyoung Kim, Sung Hoon Kim, Young Tae Kim, Jae Wook Kim

¹Department of Obstetrics and Gynecology, Yong Dong Severance Hospital, Korea. jaehoonkim@yumc.yonsei.ac.kr
²Department of Pathology, Yong Dong Severance Hospital, Korea.
³Department of Obstetrics and Gynecology, Severance Hospital, Yonsei University Collage of Medicine, Seoul, Korea.

Abstract

Uterine sarcomas are rare tumors of mesodermal origin and constitute 2-6% of uterine malignancies. They are classified into leiomyosarcoma (LMS), malignant mixed mullerian tumors (MMMTs), and endometrial stromal sarcoma (ESS) by histologic types. Endometrial stromal sarcomas account for about 7-15% of uterine sarcomas, about 0.2% of female genital tract malignancies. Endometrial stromal sarcomas are divided into endometrial stromal nodule, low-grade endometrial stromal sarcoma, and high-grade endometrial stromal sarcoma on the basis of mitotic activity and vascular invasion. Clinical outcome of low-grade endometrial sarcoma is better than that of high-grade endometrial stromal sarcoma and has a propensity for slow metastasis. We have experienced a case of low-grade endometrial stromal sarcoma with multiple metastasis in a 41-year-old woman and was treated by surgical resection and combination chemotherapy, which is presented with a review of brief literature.

Key Words: Low-grade endometrial stromal sarcoma (ESS), Multiple metastasis