Clinical significance of serum carbohydrate antigen 19-9 in ovarian mature cystic teratoma.

Lim, Seung Chul; Moon, Yeo Jung; Kim, Sang Wun; Yoon, Bo Sung; Nahm, Eun Ji; Kim, Jae Hoon; Kim, Young Tae; Kim, Jae Wook; Kim, Sunghoon

Original Article

Korean Journal of Obstetrics & Gynecology 2006;49(9):1876-1880.
Published online September 1, 2006.

Clinical significance of serum carbohydrate antigen 19-9 in ovarian mature cystic teratoma.

Seung Chul Lim, Yeo Jung Moon, Sang Wun Kim, Bo Sung Yoon, Eun Ji Nahm, Jae Hoon Kim, Young Tae Kim, Jae Wook Kim, Sunghoon Kim

¹Department of Obstetrics and Gynecology, Yonsei University College of Medicine, Korea. shkim70@yumc.yonsei.ac.kr
²Women's Cancer Clinic, Yonsei University College of Medicine, Korea.

Abstract

OBJECTIVE
This study is to determine serum carbohydrate antigen (CA) 19-9 levels in ovarian mature cystic teratoma (MCT) as a possible differential diagnostic tool. METHODS: The study group was composed of 201 patients who underwent removal of ovarian MCT and pathologically confirmed at Yonsei University Medical Center from January 2001 to July 2005. All of them were tested for serum CA19-9 levels before operation. Their data was compared with routine gynecologic evaluation group who showed normal serum CA19-9 level. Statistical analysis was carried out with t-test and Pearson correlation by SPSS version 12.0. RESULTS: Serum CA19-9 level was significantly elevated in the patients with ovarian MCT (p=0.011). Serum CA19-9 level and size of MCT showed positive correlation (p=0.009). Moreover, postoperative serum CA19-9 level showed significant decrease, compared to preoperative level (p=0.007). CONCLUSION: Serum CA19-9 can be used as an effective method for differential diagnosis of ovarian MCT, and it is proper to be used as a postoperative follow-up test.

Key Words: Ovarian mature cystic teratoma, CA19-9