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Korean Journal of Obstetrics & Gynecology 2006;49(8):1706-1711.
Published online August 1, 2006.
+764 G/A Mutation of Inhibin-alpha Gene in Korean Patients with Idiopathic Premature Ovarian Failure.
Gyoung Hoon Lee, Young Min Choi, Jong Mi Kim, Jin Ju Kim, Kyu Ri Hwang, Seung Yup Ku, Kyu Sup Lee, Byung Moon Kang, Byung Koo Yoon, Myoung Seok Han, Byung Chul Jee, Chang Suk Suh, Seok Hyun Kim, Jung Gu Kim, Shin Yong Moon
1Department of Obstetrics and Gynecology, Gachon Medical School, Korea.
2Department of Obstetrics and Gynecology, Seoul National University College of Medicine, Korea. ymchoi@snu.ac.kr
3Institute of Reproductive Medicine and Population, Medical Research Center, Seoul National University College of Medicine, Korea.
4Healthcare System Gangnam Center, Seoul National University College of Medicine, Korea.
5Department of Obstetrics and Gynecology, Boramae Hospital, Korea.
6Department of Obstetrics and Gynecology, Pusan National University College of Medicine, Korea.
7Department of Obstetrics and Gynecology, University of Ulsan, Korea.
8Department of Obstetrics and Gynecology, Sunkyunkwan University School of Medicine, Korea.
9Department of Obstetrics and Gynecology, Dong-A University College of Medicine, Korea.
Abstract
OBJECTIVE
To evaluate the incidence of the +769 G/A mutation of inhibin-alpha gene in Korean patients with idiopathic premature ovarian failure. DESIGN: DNA analysis of the mutation. METHODS: One hundred patients with idiopathic premature ovarian failure (POF) were recruited. Patient with known causes of premature ovarian failure were excluded: cytogenetic abnormalities, prior chemotherapy, prior bilateral oophorectomy and autoimmune disease, etc. DNA was extracted from peripheral blood and the +769 G/A variant of Inhibin-alpha gene (INH-alpha) was analyzed by polymerase chain reaction (PCR) and restriction fragment length polymorphism using restriction enzyme BbvI. RESULTS: We didn't find any case of +769 G/A variant in Inhibin-alpha gene in 100 Korean patients with idiopathic POF. CONCLUSION: This result suggests that in contrary to the recent data reported on the Asian population, the +769 G/A variant in inhibin-alpha gene may not exist in Korean patients with idiopathic POF.
Key Words: Premature ovarian failure (POF), Inhibin-alpha, +769 G/A variant, Korean women


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