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Korean Journal of Obstetrics & Gynecology 2006;49(7):1584-1591.
Published online July 1, 2006.
A Case of Two Sets of Monozygotic Twins after ICSI and Blastocyst Transfer.
Hyun Jung Lee, Young Sik Choi, Jung Ryeol Lee, Youn Kyung Chung, Byung Chul Jee, Seung Yup Ku, Chang Suk Suh, Young Min Choi, Jung Gu Kim, Shin Yong Moon, Seok Hyun Kim
1Department of Obstetrics and Gynecology, College of Medicine, Seoul National University, Seoul, Korea. seokhyun@snu.ac.kr
2Institute of Reproductive Medicine and Population, Medical Research Center, Seoul National University, Seoul, Korea.
One of the most important complications in assisted reproductive technology (ART) is multiple pregnancy, which is associated with an increased risk of maternal and perinatal complications. There have been several attempts to achieve the highest pregnancy rates while minimizing multiple pregnancy rates in in vitro fertilization and embryo transfer (IVF-ET). One approach for this purpose is extended embryo culture and transfer of fewer (one or two) blastocysts. However, there are emerging concerns about the increase of the risk for embryo splitting and subsequent monozygotic multiple pregnancy with this approach. Recently, there have been several reports on the possible increased risk of monozygotic twinning after extended embryo culture and blastocyst transfer. We have experienced a case of two sets of monozygotic twins after intracytoplasmic sperm injection (ICSI) and transfer of two blastocysts. We report the first case of pregnancy of monozygotic twins after blastocysts transfer with a brief review of literature in Korea.
Key Words: Monozygotic twin, Blastocyst transfer, Intracytoplasmic sperm injection (ICSI), Assisted reproductive technology (ART)
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