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Korean Journal of Obstetrics & Gynecology 2006;49(6):1258-1266.
Published online June 1, 2006.
Expression of HER-2/neu Oncoprotein in Epithelial Ovarian Cancer.
Dae Hoon Jeong, Young Nam Kim, Young Mi Park, In Ho Cho, Young Jin Seo, Young Sil Son, Su Jeon Jeong, Kyung Bok Lee, Moon Su Sung, Ki Tae Kim, Hye Kyoung Yoon
1Department of Obstetrics and Gnecology, Busan Paik Hospital, College of Medicine, Inje University, Busan, Korea. obgynjeong@hanmail.net
2Paik Institute for Clinical Research, Busan Paik Hospital, College of Medicine, Inje University, Busan, Korea.
3Department of Pathology, Busan Paik Hospital, College of Medicine, Inje University, Busan, Korea.
Abstract
OBJECTIVE
To evaluate the significance of the expression of HER-2/neu oncoprotein as a prognostic factor, we retrospectively examined its overexpression rates in epithelial ovarian cancer and their relationships with prognostic factors. METHODS: Immunohistochemistry for Her-2/neu oncoprotein was performed on formalin-fixed, paraffin-embedded tissues from 45 epithelial ovarian cancer operated between 1999 and 2002. We analyzed relationships between the overexpression of HER-2/neu oncoprotein and prognostic factors including age, histologic type, surgical stage, residual tumor > or =2 cm, and recurrence. RESULTS: The rate of overexpression of HER-2/neu oncoprotein in epithelial ovarian cancer was 31.1% (14/47). The overexpression of HER-2/ neu oncoprotein showed associations with residual tumor > or =2 cm (p=0.049) and recurrence (p=0.029) in univariate analysis. But, there were no associations between the overexpression of HER-2/neu oncoprotein and overall survival. CONCLUSION: The overexpression of HER-2/neu oncoprotein was associated with residual tumor and recurrence in univariate analysis, but appeared to have no prognostic significance for overall survival of epithelial ovarian cancer. Further and larger prospective studies using multivariate analysis are necessary to establish the clinical applicability of these observations.
Key Words: HER-2/neu oncogene, Epithelial ovarian cancer, Immunohistochemistry


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