A Clinical Study of 25 Cases of Uterine Papillary Serous Carcinoma.

Lee, Hyun Jung; Lee, Keum Jung; Kim, Min Ji; Seo, Back Kyung; Yu, Young; Lim, Kyung Taek; Seong, Seok Ju; Park, Chong Taik; Shim, Jae Uk; Lee, Ki Heon

Case Report

Korean Journal of Obstetrics & Gynecology 2006;49(5):1131-1137.
Published online May 1, 2006.

A Clinical Study of 25 Cases of Uterine Papillary Serous Carcinoma.

Hyun Jung Lee, Keum Jung Lee, Min Ji Kim, Back Kyung Seo, Young Yu, Kyung Taek Lim, Seok Ju Seong, Chong Taik Park, Jae Uk Shim, Ki Heon Lee

¹Department of Obstetrics and Gynecology, Samsung Cheil Hospital and Women's Healthcare Center, College of Medicine, Sungkyunkwan University, Seoul, Korea. oncolim.lim@samsung.com
²Department of Obstetrics and Gynecology, Gwangmyoung Cheil Woman's Clinic, Gwangmyoung, Korea.

Abstract

OBJECTIVE
Uterine papillary serous carcinoma (UPSC) has been recognized as an aggressive tumor characterized by deep myometrial invasion and reported high recurrence and low survival rates. METHODS: We retrospectively investigated the clinicopathologic findings and analyzed the survival rate and prognostic factors in 25 patients with UPSC who were surgically staged at the oncology department between January 1994 and December 2003. RESULTS: The mean age of the cases was 55.8 (range: 45-69) years. The most frequent presenting symptom was abnormal uterine bleeding (88%). According to FIGO staging, seven of the cases were stage I, six of the cases were stage II, eleven of the cases were stage III, and one case was stage IV. Mean follow up period is 42.7 months (range: 9-123 months). Overall survival rate was 80 percent. The recurrence was seen in 5 patients (25%). CONCLUSION: Univariate analysis showed that invasion of uterine serosa, ovarian and tubal metastasis, and positive peritoneal washing cytology were significantly associated with prediction of prognosis. In multivariate analysis, tubal metastasis was an independent prognostic factor for overall survival.

Key Words: Uterine papillary serous carcinoma (UPSC), Prognostic factor, Survival rate