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Korean Journal of Obstetrics & Gynecology 2006;49(3):660-666.
Published online March 1, 2006.
The clinical inflammatory reaction of Interceed(R) after laparoscopic surgery.
Young Hye Kim, Kwang Soo Kee, Hyuk Jung
1Department of Obstetrics and Gynecology, Chosun University Hospital, Korea. bimilo@hanmail.net
2Department of Obstetrics and Gynecology, Gwangju Christian Hospital, Gwangju, Korea.
Adhesions resulting from surgery may well be the most signigicant iatrogenic factor contributing to infertility and pelvic pain. Recently surgical barriers which mechanically separate opposing surfaces during tissue healing have been devised. Interceed(R) is an absorbable oxized regenerated cellulose barrier that adheres to the site of injury, converts into a gel, spontaneously maintains its position and dose not necessitate sutures. The goal of the study was whether the use of Interceed(R) elicits an inflammatory reaction when it remains foreign materials after laparoscopic surgery. METHODS: This randomized prospective study inculded 207 patients who had undergone laparoscopic operation at the department of Obstetric and Gynecology, Chosun University hospital, from January 2002 to December 2004. Of these 207 patients, 102 underwent laparoscopic operation with applying Interceed(R) (Group 1) and 107 underwent laparoscoic operation without applying Interceed(R) (Group 2). The WBC (White Blood Cell) count, ESR (Erythrocyte Sedimentation Rate), CRP (C-Reactive Protein), body temperature were compared postoperatively. P<0.05 was considered statistically signigicant. RESULTS: Preoperative WBC (White Blood Cell) count, ESR (Erythrocyte Sedimentation Rate), CRP (C-reactive protein), body temperature of two groups were no significant difference between Group 1 and 2. At postoperative 4th, 10th, 28th day, WBC (White Blood Cell) count, ESR (Erythrocyte Sedimentation Rate), CRP (C-reactive protein), body temperature, vaginal cuff tenderness of two groups were not significantly different between Group 1 and 2. DISCUSSION: We found that the use of Interceed(R) do not elicit an inflammatory reaction through laboratory finding and clinical finding although it remains foreign material after laparoscopic surgery. So we can use Interceed(R) for preventing adhesion safely.
Key Words: Interceed(R), Adhesion, Clinical inflammatory reaction

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