The analysis of prognostic factors in patients with epithelial ovarian cancer.

Yun, Jung Hye; Lee, Hyun Young; Park, Hye Won; Shin, Jin Woo; Lee, Joung Min; Park, Chan Yong

Original Article

Korean Journal of Obstetrics & Gynecology 2006;49(3):566-571.
Published online March 1, 2006.

The analysis of prognostic factors in patients with epithelial ovarian cancer.

Jung Hye Yun, Hyun Young Lee, Hye Won Park, Jin Woo Shin, Joung Min Lee, Chan Yong Park

Department of Obstetrics and Gynecology, Gachon Medical School, Gil Hospital, Incheon, Korea. kgo02@hanmail.net

Abstract

OBJECTIVE
To determine pathologic variables associated with overall survival and disease free survival of patients with epithelial ovarian cancer. METHODS: Diesease free survival and overall survival of 80 ovarian cancer patients treated with primary surgery between January 1997 and December 2003 at our center were compared about various histopathologic variables. Survival analyses were performed by the Kaplan-Meier curves and the log-rank test. Independent prognostic factors were determined by Cox's proportional hazards model. RESULTS: With regard to disease free survival, univariate analysis revealed no significant differences in subgroups according to age category, histologic type and grade. However, significant differences in disease free survival were found in stage category and residual tumor volume. Among these significant subgroups, the Cox-proportional hazards model showed that residual tumor volume was the only independent prognostic factor. There were significant differences in the overall survival of patients in subgroups according to stage categoty and residual tumor volume. Multivariate analysis revealed that residual tumor volume was the only independent significant adverse prognostic factor. CONCLUSION: Our results showed that only residual tumor volume was the independent prognostic factor of disease free survival and overall survival in epithelial ovarian cancer patients.

Key Words: Epithelial ovarian cancer, Residual tumor, Survival