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Korean Journal of Obstetrics & Gynecology 2006;49(2):383-390.
Published online February 1, 2006.
Lack of Association between L-myc Single Nucleotide Polymorphism and Cervical Cancer Susceptibility and Invasiveness in Korean Women.
Woong Ju, Eun Kyoung Shin, So Hyun Lee, Jae Weon Kim, Noh Hyun Park, Yong Sang Song, Seung Cheol Kim, Soon Beom Kang, Hyo Pyo Lee
1Department of Obstetrics and Gynecology, College of Medicine, Ewha Womans University, Seoul, Korea.
2Medical Research Institute, College of Medicine, Ewha Womans University, Seoul, Korea.
3Department of Obstetrics and Gynecology, College of Medicine, Seoul National University, Seoul, Korea. kjwksh@snu.ac.kr
4Cancer Research Institute, College of Medicine, Seoul National University, Seoul, Korea.
5Human Genome Research Institute, College of Medicine, Seoul National University, Seoul, Korea.
Abstract
OBJECTIVE
The aim of this investigation was to analyze the association between a single nucleotide polymorphism (SNP) in L-myc gene (T3109G) and the cervical cancer susceptibility or invasiveness in Korean women. METHODS: The blood samples of 231 cervical cancer patients and 332 non-cancer control subjects who managed at Seoul National University Hospital from 1999 to 2002 were collected. Polymorphism in L-myc (T3109G) was determined using TaqMan method. Allele frequency and genotype distribution in the cervical cancer group were compared with those of the control group to determine whether this polymorphism elevates the susceptibility of Korean women to the cervical cancer. The relationship between this SNP and cancer invasiveness was also evaluated by collating clinicopathologic data of those in the cancer group, such as age, FIGO stage, histologic type, lymph node metastasis and parametrial invasion. RESULTS: In the cervical cancer group, the allele frequency of G was 47.6%, in the control group 48.5%, showing no significant difference (p=0.808). Similarly the genotypes with TG or GG showed no increased risk for the cervical cancer compared with TT genotype. A subgroup analysis of the clinicopathologic parameters in cancer group also showed no significant difference suggesting the lack of an association between SNP of the L-myc and the cervical cancer invasiveness. CONCLUSION: This study shows that Korean women with specific polymorphism in L-myc are neither more susceptible to develop the cervical cancer nor more vulnerable for the cancer progression.
Key Words: Single nucleotide polymorphism, L-myc, Cervical cancer, Susceptibility, Invasiveness


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