| Relationship between the Expression of COX-1, COX-2, p53 and VEGF and Prognostic factors in Squamous cell carcinoma of Uterine cervix. |
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Jong Kil Joo, Dong Hyung Lee, Ki Hyung Kim, Yong Jin Na, Chang Hoon Lee, Man Soo Yoon |
1Department of Obstetrics and Gynecology, College of Medicine, Pusan National University, Busan, Korea. msyoon@pusan.ac.kr
2Department of Pathology, College of Medicine, Pusan National University, Busan, Korea. |
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| Abstract |
OBJECTIVE
The aim of this study was to examine that COX-1, COX-2, p53 and VEGF expression are associated with prognostically worse pathological variables and to investigate whether the enhanced COX-2, tumor microvessel density and VEGF expression is showed in invasive cervical cancer. METHODS: From January 1998 to December 2001, sixty-three cases of paraffin-embedded cervical specimens were obtained by surgical resection in the Pusan National University Hospital. All tissues were subjected to immunohistochemical staining for COX-1, COX-2, p53, VEGF and microvessel density. Clinical factors such as age, FIGO stage and pelvic lymph node metastasis were evaluated. RESULTS: In COX-1 expression, no staining and cells staining positive less than 10% were 49, 13 cases, respectively. In contrast, COX-2 expressions was demonstrated in the cells staining positive 10% to 50% and greater than 50% were 25, 17 cases, respectively. The positivities of p53 and VEGF were 68.3% (43/63), 77.8% (49/63), respectively. There was a significant correlation between COX-2 and VEGF expression (p<0.05) in cervical cancer. Also the relationship existed between VEGF and microvessel count. But there was no correlation between COX-2, microvessel count and clinicopathologic factors in cervical cancer. CONCLUSION: These findings provide evidence that the expression of COX-2 and VEGF may be involved in the promotion of angiogenesis in cervical cancer. |
| Key Words:
COX-1, COX-2, VEGF, Cervical cancer |
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