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Korean Journal of Obstetrics & Gynecology 2005;48(6):1555-1562.
Published online June 1, 2005.
A Case of Endometrial Cancer with Hereditary Non-Polyposis Colorectal Cancer (HNPCC).
Jae Hee Yoon, Seon Kyung Lee, Suk Hee Lee, Seo Yun Tong, So Ra Kim, In Gu Do, Seung Bo Kim
1Department of Obstetrics and Gynecology, College of Medicine, Kyung Hee University, Seoul, Korea. andy2155@korea.com
2Department of Pathology, College of Medicine, Kyung Hee University, Seoul, Korea.
Abstract
Endometrial cancer is the most common malignant disorder that can be associated with hereditary non-polyposis colorectal cancer (HNPCC), which is known as Lynch II syndrome. HNPCC is a polyposis of the colon which is inherited in an autosomal dominant pattern and can cause cancer in other organs, especially in the endometrium. The overall risk of a women with HNPCC to develop endometrial cancer is 40-60%, much higher than the 3% of the general population of women. The average age of developing endometrial cancer of a women with HNPCC is 45 years of age and is often found before development of colon cancer. We have recently experienced a case of de novo type of hereditary non-polyposis colorectal cancer associated with endometrial cancer, hence we are reporting this case with a brief review of literatures.
Key Words: Endometrial cancer, Hereditary non-polyposis colorectal cancer (HNPCC), MSI (microsatellite instability), MMR (mismatch repair) gene


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