CYP1A1 Gene Polymorphism in Korean Women with Endometriosis.

Lee, Gyoung Hoon; Choi, Young Min; Lee, Taek Hoo; Ku, Seung Yup; Jun, Jong Kwan; Park, Sung Hyo; Chang, Eun Ran; Park, Noh Hyun; Kang, Soon Beom; Cho, Soo Youn; Park, In Ae; Jee, Byung Chul; Suh, Chang Suk; Kim, Seok Hyun; Kim, Jung Gu; Moon, Shin Yong

Original Article

Korean Journal of Obstetrics & Gynecology 2005;48(6):1484-1489.
Published online June 1, 2005.

CYP1A1 Gene Polymorphism in Korean Women with Endometriosis.

Gyoung Hoon Lee, Young Min Choi, Taek Hoo Lee, Seung Yup Ku, Jong Kwan Jun, Sung Hyo Park, Eun Ran Chang, Noh Hyun Park, Soon Beom Kang, Soo Youn Cho, In Ae Park, Byung Chul Jee, Chang Suk Suh, Seok Hyun Kim, Jung Gu Kim, Shin Yong Moon

¹Department of Obstetrics and Gynecology, Seoul National University College of Medicine, Korea. ymchoi@snu.ac.kr
²Institute of Reproductive Medicine and Population, Medical Research Center, Seoul National University College of Medicine, Korea.
³Department of Pathology, Seoul National University College of Medicine, Korea.
⁴Department of Obstetrics and Gynecology, Kyungpook National University School of Medicine, Korea.

Abstract

OBJECTIVE
To explore the association of the CYP 1A1 gene polymorphism with the risk of endometriosis in a Korean population. DESIGN: Case-control study METHODS: Two-hundred fifty two Korean women with surgically or histologically diagnosed endometriosis of stage I-IV (ASRM, 1997) were recruited, and 203 women with no evidence of endometriosis served as controls. CYP1A1 gene MspI polymorphism was analyzed by polymerase chain reaction (PCR) and restriction fragment length polymorphism analysis. RESULTS: There was no significant difference in the genotype or allele distribution of CYP1A1 gene polymorphism between patients with endometriosis and controls. And when classified by stage, there was also no significant difference in the genotype and allele distribution of CYP1A1 gene MspI polymorphism between patients with stage I-II or stage III-IV endometriosis and controls. CONCLUSION: These results suggest that CYP1A1 gene MspI polymorphism is not associated with the risk of endometriosis in the Korean women.

Key Words: Endometriosis, CYP1A1, Polymorphism, Korean women