| A Clinical Study on Malignant Germ Cell Tumor of Ovary. |
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Yong Sik Kim, Myoung Sook Jo, Cheol Hong Kim, Ki Min Kim, Moon Kyo Jo, So Yi Rim, Da Rin Ki, Jae Young Lee, Seok Mo Kim, Ho Sun Choi |
1Department of Obstetrics and Gynecology, College of Medicine, Chonnam National University, Gwangju, Korea. seokmo2001@yahoo.co.kr
2Department of Obstetrics and Gynecology, St. Garollo Hospital, Suncheon, Korea. |
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| Abstract |
OBJECTIVE
to evaluate the clinicopathologic characteristics of patients with ovarian malignant germ cell tumor. METHODS: We reviewed records of women who had malignant germ cell tumors of the ovary from 1991-2000. RESULTS: Thirty-seven women had surgical resections of malignant ovarian germ cell tumors and most received adjuvant therapy. Twenty-five women (68%) presented with stage I disease, and 12 (32%) had more advanced disease. Histology subtypes were: immature teratoma (n=16), dysgerminoma (n=9), yolk sac tumor (n=8), choriocarcinoma (n=2), embryonal carcinoma (n=1), and mixed germ cell tumor (n=1). The frequency of positive tumor markers were aFP, CA-125, beta-hCG, CA 19-9 and LDH in decreasing order. The mean age of the patients at presentation was 23.9 years (4-58). Surgical management of the 32 patients consisted of unilateral oophorectomy, or salpingo-oophorectomy, 1 woman with stage III disease underwent bilateral salpingo-oophorectomy and 4 women underwent total abdominal hysterctomy, bilateral or unilateral adnexectomy. Thirty-two women were treated with adjuvant combination chemotherapy (BEP, VAC, VBP) according to indications. The 5-year survival rate was 100%, and 5-year disease-free rate was 91.8%. Among twelve patients who attempted pregnancy, 8 succeeded in it and delivered normal full term babies. CONCLUSION: Current therapeutic strategies can allow most women with ovarian malignant germ cell tumors to have conservative surgery without compromising survival and to preserve their reproductive potential. |
| Key Words:
Malignant germ cell tumor, Tumor marker, Chemotherapy |
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