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Korean Journal of Obstetrics & Gynecology 2005;48(3):701-708.
Published online March 1, 2005.
The expression of epidermal growth factor and fibroblast growth factor-2 in the eutopic endometrium of women with endometriosis.
Jeong Won Choi, Hyang Ah Lee, Sa Ra Lee, Seok Ho Hong, Hee Young Nah, Young Jin Lee, Sung Hoon Kim, Hee Dong Chae, Chung Hoon Kim, Byung Moon Kang
Department of Obstetrics and Gynecology, College of Medicine, University of Ulsan, Asan Medical Center, Seoul, Korea. Kimsung@amc.seoul.kr
Abstract
OBJECTIVE
To compare the expression of epidermal growth factor (EGF) and fibroblast growth factor-2 (FGF-2) in the eutopic endometrium of women with and without endometriosis. METHODS: Thirty-two women with histologically confirmed endometriosis after laparotomy or laparoscopy were recruited. Twenty-eight women with carcinoma in situ of the uterine cervix, uterine myoma and ovarian tumor but no evidence of endometriosis served as control. Following isolation of total RNA from endometrial tissue and reverse transcription, cDNA samples were amplified by real time PCR to quantify the expression of EGF, FGF-2, and GAPDH genes. RESULTS: Including all menstrual phases, the levels of mRNA expressions of EGF and FGF-2 were not different between the eutopic endometrium of women with and without endometriosis. When analyzed separately according to the 6 menstrual phases, no differences were found between the two groups, either. CONCLUSION: This study shows that the levels of mRNA expressions of EGF and FGF-2 in the eutopic endometrium were not different between women with and without endometriosis.
Key Words: EGF, FGF-2, Endometriosis, Endometrium, Angiogenesis


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