Correlation of Progesterone Challenge Test and Endometrial Thickness in Postmenopausal Women.

Kwack, Min Jung; Joo, Seon Ha; Kim, Kwang Hwan; Park, Choong Hak; Park, Jin Wan

Original Article

Korean Journal of Obstetrics & Gynecology 2005;48(3):575-580.
Published online March 1, 2005.

Correlation of Progesterone Challenge Test and Endometrial Thickness in Postmenopausal Women.

Min Jung Kwack, Seon Ha Joo, Kwang Hwan Kim, Choong Hak Park, Jin Wan Park

¹Department of Obstetrics and Gynecology, College of Medicine, Dan-Kook University, Cheonan, Korea. parkdkog@dankook.ac.kr
²Deptartment of Medical Record, College of Medicine, Dan-Kook University, Cheonan, Korea.

Abstract

OBJECTIVE
The aim of this study is to assess the correlation of progesterone challenge test (PCT) and endometrial thickness as a primary screening test for endometrial pathology in postmenopausal women prior to hormonal replacement therapy (HRT). METHODS: 92 postmenopausal women were measured serum estradiol (E2) level, endometrial thickness by transvaginal ultrasonography, and followed by PCT before HRT. And we compared the results of PCT with endometrial thickness and E2 levels. RESULTS: Women with a positive result of PCT in 32% of case and 75.9% of positive test showed endometrial thickness 4 mm or more. However 60.3% of negative test showed endometrial thickness 4 mm or more. This resulted in a PPV=76%, NPV=40%, sensitivity=37%, and specificity=78%. Mean serum E2 was significantly higher in patient with positive PCT but serum E2 showed no positive correlation with endometrial thichness (CI 95%, P

Key Words: Progesterone challenge test, Endometrial thickness, Menopause