| A case of acute lymphocytic leukemia in pregnancy. |
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Hyun Jung Choi, Yong Won Park, June Won Cheong, You Hong Min, Ja Yong Kwon, Han Sung Kwon, Young Han Kim, Sung Hoon Kim |
1Department of Obstetrics and Gynecology, Yonsei University College of Medicine, Seoul, Korea. shkim70@yumc.yonsei.ac.kr
2Department of Internal Medicine, Yonsei University College of Medicine, Seoul, Korea.
3Institute of Woman's Life Science, Yonsei University College of Medicine, Seoul, Korea. |
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| Abstract |
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The incidence of acute leukemia in pregnancy is estimated to be about 1 per 75000 pregnancies, and the incidence of lymphocytic leukemia is known to be lower than myelocytic leukemia. Pregnancy dose not affect the course of acute leukemia, but thrombocytopenia, anemia and leukopenia resulting from leukemia may lead to hemorrhage, infection, and insufficient supply of oxygen and nutrition to fetus. The most important factor for chemotherapy is gestational age. Since no evidence on adverse effect of chemotherapeutic agents on fetus when given after the first trimester, aggressive chemotherapy is recommended during pregnancy. However, during chemotherapy, caution regarding risk of spontaneous abortion, intrauterine fetal growth retardation, teratogenicity, intrauterine fetal death, fetal immunosupression and preterm labor should be taken. Acute leukemia in pregnancy is extremely rare, so treatment and management of the pregnant mother bearing viable fetus in her 3rd trimester is not established clearly. We experienced a patient with acute lymphocytic leukemia who was first diagnosed at 27 gestational weeks and immediately started with chemotherapy. But due to preterm labor and impending fetal distress, emergency cesarean section was performed at 28 gestational weeks. We present this patient along with past experiences of acute leukemia in pregnancy. |
| Key Words:
Acute lymphocytic leukemia |
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