| Survivin and Bcl-2 expression in eutopic endometrium with and without endometriosis. |
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Yun Jin Kim, Young Ah Kim, Han Seong Kim, Woon Hee Suh, Kyung Koo Kim, Doo Young Chang, Myung Kwon Jeon, Eung Soo Lee |
1Department of Obstetrics and Gynecology, College of Medicine, Inje University, Ilsan Paik Hospital, Kyunggi, Korea. camanbal@ilsanpaik.ac.kr
2Department of Pathology, College of Medicine, Inje University, Ilsan Paik Hospital, Kyunggi, Korea. |
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| Abstract |
OBJECTIVE
To examine expression of survivin and Bcl-2 in eutopic endometrium with endometriosis and without endometriosis by immunohistochemical stain. METHODS: Expression of survivin and Bcl-2 was immunohistochemically investigated in eutopic endometrium with endometriosis (n=30, study group I; laparoscopy-proved endometriosis, study group II; adenomyosis) or without endometriosis (n=34, control group). The score of immunohistochemical staining was evaluated semi-quantitative method modified by Sinicrope and Lu. Statistical analyses was carried out using one-way ANOVA with Turkey test. RESULTS: Survivin expression was significantly higher in nucleus of glandular epithelium of eutopic endometrium with endomtriosis compared to that without endometriosis (p<0.05). Increased expression of Bcl-2 was found in glandular epithelium of eutopic endometrium with endometriosis than without endometriosis, but there was no significantly difference. CONCLUSION: Our findings suggest that increased survivin expression may contribute to survival of endometriosis. Moreover, survivin could play an important role in pathogenesis of endometriosis. |
| Key Words:
Endometriosis, Eutopic endometrium, Survivin, Bcl-2 |
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