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Korean Journal of Obstetrics & Gynecology 2005;48(1):240-246.
Published online January 1, 2005.
A Case of Persistent Metastatic Gestational Trophoblastic Disease after Partial Hydatidiform Mole.
Jin Hee Lee, Bong Seok Kim, Jong Ho Chang, Yoon Sook Kim, Jong Su Kim, Seung Do Choi, Jae Gun Sunwoo, Dong Han Bae, Seung Ha Yang
1Department of Obstetrics and Gynecology, University of Soonchunhyang, College of Medicine, Soonchunhyang University Chunan Hospital, Chunan, Korea. jinnie0927@hanmail.net
2Department of Pathology, University of Soonchunhyang, College of Medicine, Soonchunhyang University Chunan Hospital, Chunan, Korea.
Abstract
Persistent tumor, usually non-metastatic, develops in approximately 4% of patients with a partial mole, and chemotherapy is required to achieve remission. Following evacuation of hydatidiform mole, careful hCG monitoring is mandatory since it is the most reliable and sensitive method for the early detection of gestational trophoblastic disease. In carefully selected patients in whom the risk of developing gestational trophoblastic disease is significant or when the availability of hCG testing is suboptimal, chemoprophylaxis has been shown to decrease the risk of gestational trophoblastic tumor. We report here a case of patient, 23- year-old woman who experienced unusual course after the evacuation of a partial mole and markedly elevated serum beta-hCG levels. The patient developed persistent metastatic gestational trophoblastic disease and was successfully treated with 3 courses of EMA-CO.
Key Words: Partial hydatidiform mole, Persistent metastatic gestational trophoblastic disease, Chemotherapy


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