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Korean Journal of Obstetrics & Gynecology 2005;48(1):29-35.
Published online January 1, 2005.
Correlation of Serum Vascular Endothelial Growth Factor and Matrix Metalloproteinase-2 in Patients Complicated with Preeclampsia and Normotensive Pregnant Women.
Kyung Ju Lee, Min Jeong Oh, Hai Joong Kim, Sun Haeng Kim, Jae Kwan Lee, Jun Young Hur, Ho Suk Saw, Yong Kyun Park
1Department of Obstetrics and Gynecology, College of Medicine, Pocheon CHA University, Kangnam CHA General Hospital, Korea.
2Department of Obstetrics and Gynecology, College of Medicine, Korea University, Seoul, Korea. mjohmd@korea.ac.kr
Abstract
OBJECTIVE
The aim of this study is to evaluate whether serum levels of vascular endothelial growth factor (VEGF) and matrix metalloproteinase-2 (MMP-2) are different between normotensive pregnant women and preeclampsia patients and also to investigate the relationship of VEGF and MMP-2. METHODS: We analyzed the serum levels of VEGF and MMP-2 in patients with preeclampsia (n=20) and normotensive pregnant women (n=20). RESULTS: Of the normotensive pregnant and preeclampsia women, the serum VEGF levels are 0.28 +/- 0.14 ng/mL 2.39 +/- 0.75 ng/mL, the serum MMP-2 levels are 11.81 +/- 1.75 ng/mL, 31.99 +/- 6.5 ng/mL respectively. These serum levels are higher in preeclampsia patients than normotensive pregnant women (P<0.001) The serum VEGF levels positively relate with plasma MMP-2 levels in preeclampsia (P<0.05, r=0.78). CONCLUSION: The serum VEGF levels highly correlate with the increased MMP-2 levels in preeclampsia, which may contribute the pathophysiology of preeclampsia.
Key Words: Vascular endothelial growth factor, Matrix metalloproteinase-2, Preeclampsia


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