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Korean Journal of Obstetrics & Gynecology 2004;47(9):1738-1742.
Published online September 1, 2004.
Perinatal Prognosis in Cystic Hygroma According to the Presence of Septation.
Suk Joon Chang, Jong Hee Kwon, Yun Kyung Lim, Jeong In Yang, Haeng Soo Kim, Hee Sug Ryu
Department of Obstetrics and Gynecology, Ajou University School of Medicine, Suwon, Korea.
We evaluated the association between perinatal prognosis and the presence of septation in cystic hygroma deteted by antenatal ultrasonography. METHODS: During a 5-year period, 65 cases of cystic hygroma were diagnosed by antenatal ultrasonography. 31 cases were included in this study. Fetal karyotyping, hydrops, and associated anomalies were compared between septated and non-septated groups. Statistical analysis was performed using Fisher exact test. RESULTS: There were 24 cases of septated cystic hygromas, and 7 cases of nonseptated cystic hygromas. Sixty-three percent of the septated cystic hygromas had accompanying hydrops and other anomalies (15/24), versus 28% (2/7) in the nonseptated group (p=0.022). Other anomalies such as cleft lip and palate, omphalocele, and club foot were more frequently seen in the septated group. Nine of 14 cases of septated cystic hygroma that underwent karyotying showed aneuploidy (64%), compared with 0% (0 of 6 cases) aneuploidy rate in the nonseptated cystic hygroma group (p=0.014). CONCLUSION: Abnormal fetal karyotyping, hydrops, and other anomalies are more likely to be associated in fetuses with septated cystic hygroma. So, the presence of septation may be the useful prognostic indicator of cystic hygroma.
Key Words: Cystic hygroma, Septation, Antenatal ultrasonography, Perinatal prognosis

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