A Case of Juvenile Granulosa Cell Tumor.

Chang, Jae Hyuk; Jung, Young Hwan; Cho, Kyoung Hyun; Chung, Ji Youn; Moon, Chong Soo; Seo, Soo Hyung; Park, Yang Suh

Case Report

Korean Journal of Obstetrics & Gynecology 2003;46(8):1614-1619.
Published online August 1, 2003.

A Case of Juvenile Granulosa Cell Tumor.

Jae Hyuk Chang, Young Hwan Jung, Kyoung Hyun Cho, Ji Youn Chung, Chong Soo Moon, Soo Hyung Seo, Yang Suh Park

Department of Obstetrics and Gynecology Hallym University College of Medicine, Seoul, Korea.

Abstract

Granulosa cell tumors costitute 1% to 2% of all ovarian tumors and occur mostly in adult women. Juvenile granulosa cell tumor (JGCT) differs from the adult type in clinical and pathologic features as well as biological behavior. Usually associated with estrogen production, the tumor leads to endocrinologic symptoms such as isosexual precocity in premenarcheal girl and menstrual irregularities or amenorrhea in postpubertal woman. JGCT is diagnosed in early stage with favorable prognosis in most cases while in more advanced stage with grave outcome. The clinical stage at the time of diagnosis is considered the most important prognostic factor. If fertility is desired in the absence of contralateral or pelvic involvement, unilateral salpingo- oophorectomy is justifiable. We experienced a case of JGCT in 22 years old woman who presented with amenorrhea and low abdominal pain, and report this case with a brief review of literatures.

Key Words: Juvenile granulosa cell tumor, Endocrinologic symptoms