Two Cases of Term Pregnancy Associated with Thrombophilia.

Joung, Tae Hwa; Chang, Sung Woon; Kim, Hyeon Chul; Kang, Suk Ho; Chang, Woo Sup; Cho, Sung Woo; Lee, Kyung Mi; Park, Ji Hyeun; Oh, Do Yeun

Case Report

Korean Journal of Obstetrics & Gynecology 2003;46(4):856-859.
Published online April 1, 2003.

Two Cases of Term Pregnancy Associated with Thrombophilia.

Tae Hwa Joung, Sung Woon Chang, Hyeon Chul Kim, Suk Ho Kang, Woo Sup Chang, Sung Woo Cho, Kyung Mi Lee, Ji Hyeun Park, Do Yeun Oh

¹Department of Obstetrics and Gynecology, College of Medicine Pocheon CHA University, Pocheon, Korea.
²Department of Internal Medicine, College of Medicine Pocheon CHA University, Pocheon, Korea.

Abstract

These are natural inhibitors of coagulation, and deficiencies of any of these factors is referred to as thrombophilia. The identified main causes of thrombophilia are deficiencies of antithrombin III, protein C, or protein S, resistance to actived protein C associated with Factor V Leiden mutation, and inherited hyperhomocystinemia. Inherited and acquired thrombophilias may also contribute to pathophysiological processes involved in recurrent pregnancy loss, fetal death, intrauterine growth restriction, placental abruption, placental infarction, and pre-eclampsia. Various therapeutic protocols with low-molecular-weight heparin (LMWH) were used. because it is associated with a low incidence of osteoporosis and thrombocytopenia. We experienced the two cases of successful deliveries by Cesarean section following a successful pregnancy maintenance in thrombophilia. we administered LMWH to prevent thromboembolism. one patient was the primi-gravidarum, with inherited thrombophilia, who has the familial history of pulmonary embolism and deep vein thrombosis. the other was the multi-gravidarum, with acquired thrombophilia, who has the past medical history of pulmonary embolism.

Key Words: Thrombophilia, Thromboembolism, Low-molecular-weight heparin (LMWH)