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Korean Journal of Obstetrics & Gynecology 2003;46(4):764-770.
Published online April 1, 2003.
The Concentration of IL-8 and VEGF in Cervicovaginal Washing Fluid and Sera with Cervical Cancer: Case-Control Study.
Yong Beom Kim, Hye Won Jeon, Sang Soo Seo, Jae Weon Kim, Noh Hyun Park, Yong Sang Song, Soon Beom Kang, Hyo Pyo Lee
Department of Obstetrics and Gynecology, College of Medicine, Seoul National University, Seoul, Korea.
Abstract
OBJECTIVE
The aim of this study was to evaluate the concentration of IL-8 and VEGF in serum and cervicovaginal washing fluid and to investigate whether local production of IL-8 and VEGF could be found. METHODS: Cervicovaginal washing fluid and sera were obtained from 14 patients with invasive cervical cancer and 19 patients with other benign disease who showed normal Pap smear result. The level of IL-8 and VEGF was determined by ELISA (PharMingenTM, San Diego, CA, USA). RESULTS: The mean concentration of cervicovaginal washing fluid IL-8 was 2181.7 pg/ml (+/-2235.7) in case group and 899.0 pg/ml (+/-1192.0) in control group, and the mean concentration of serum IL-8 was 230.6 pg/ml (+/-214.1) and 103.5 pg/ml (+/-138.5) respectively. With VEGF, the mean concentraiton of cervicovaginal washing fluid was 216.9 pg/ml (+/-125.4) in case group and 102.9 pg/ml (+/-138.1) in control group and of serum was 31.2 pg/ml (+/-15.6) and 17.7 pg/ml (+/-17.3) respectively. There was a significant correlation between IL-8 and VEGF in control group (spearman P=0.001 (0.858), 0.001 (0.839). 95% CI, cervicovaginal washing fluid, serum) as well as in case group (spearman P=0.001 (0.905), 0.041 (0.462). 95% CI). CONCLUSION: The concentration of IL-8 and VEGF from both serum and cervicovaginal washing fluid was significantly increased in case group than in control group. There seems to be a local production of IL-8 and VEGF in cervicovaginal tissue from the results of a significant correlation between IL-8 and VEGF in control group as well as in case group and a significant increase of the median concentration of IL-8 and VEGF in cervicovaginal washing fluid than in serum.
Key Words: Cervical cancer, IL-8, VEGF, ELISA
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