A Case of Angiomyofibroblastoma of the Vulva.

Jo, Hyang Jeong; Kim, Heung Gon; Moon, Hyung Bae

Case Report

Korean Journal of Obstetrics & Gynecology 2003;46(3):685-688.
Published online March 1, 2003.

A Case of Angiomyofibroblastoma of the Vulva.

Hyang Jeong Jo, Heung Gon Kim, Hyung Bae Moon

¹Department of Pathology and Institute of Wonkwang Medical Science, Korea.
²Department of Obstetrics and Gynecology, Wonkwang University, College of Medicine, Iksan, Korea.

Abstract

Angiomyofibroblastoma of the vulva is a recently described mesenchymal tumor. It can be distinguished from an aggressive angiomyxoma by its circumscribed borders, higher cellularity, more numerous blood vessels, the frequent presence of stromal cells, minimal stromal mucin, and rarity of erythrocyte extravasation. We experienced a case of angiomyofibroblastoma of the vulva occurring in a 52-year-old woman. The lesion was a well-circumscribed mass, measuring 4x5 cm in size. Histologically, the mass was characterized by alternating hypercellular and hypocellular edematous zones in which abundant blood vessels were irregularly distributed. The stromal cells were concentrated around the blood vessels, or loosely dispersed in the hypocellular area. Immunohistochemically, the stromal cells were diffusely reactive for vimentin, focally reactive for desmin, but not for smooth muscle actin.

Key Words: Angiomyofibroblastoma, Vulva, Aggresive angiomyxoma