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Korean Journal of Obstetrics & Gynecology 2003;46(2):410-422.
Published online February 1, 2003.
The Effects of Green Tea Extracts (Polyphenon E, EGCG) in Human Papilloma Virus Positive Cervical Lesion.
Hyun Sun Ko, Seung Won Huh, Su Mi Bae, Seung Ae Son, Jae Eun Chung, Dong Kun Jin, In Su Lee, Jeong Im Sin, Joon Mo Lee, Sung Eun Namkoong, Woong Shick Ahn
1Department of Obstetrics and Gynecology, College of Medicine, The Catholic University of Korea, Korea.
2Catholic Research Institutes of Medical Science, College of Medicine, The Catholic University of Korea, Korea.
3Departmentof Medicine, Catholic University of Daegu, Korea.
Abstract
OBJECTIVE
We tried to confirm the effects of green tea extracts (polyphenon E, EGCG) in patients with human papilloma virus (HPV) positive cervical lesion. METHODS: We divided 51 HPV positive cervical lesion patients (chronic cervicitis, mild dysplasia, moderate dysplasia and severe dysplasia) into 4 group and 37 patient as placebo control. We applied poly E ointment two times per week (27 patients), poly E ointment plus poly E capsule (8 patients), poly E capsule (6 patients), EGCG capsule (10 patients) 200 mg each for 8 to 12 weeks. RESULTS: Among 27 patients with poly E ointment group, 20 patients responded (74%), such as chronic cervicitis (12/18), mild dysplasia (4/5), moderate dysplasia (2/2) and severe dysplasia (1/2). Among 8 patients with poly E ointment and poly E capsule group, 6 patients responded (75%), 6 patients poly E capsule group responded 3 patients (50%). 10 EGCG capsule patients group responded 6 patients (60%). Overall responsive rate is 69% (35/51) in case of green tea extracted treated group and 10% (4/39) in placebo controlled group (P<0.05). CONCLUSION: The effects of green tea extract in HPV positive cervical lesion were statistically significant (P<0.05). This result suggests that green tea extract has highly potential of new treatment agent for HPV infected cervical lesion.
Key Words: Green tea Extracts, EGCG, Polyphenon E, Cervical Cancer, HPV


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