A Case of Spontaneous Pregnancy in Patient with Premature Ovarian Failure Who Has a Y Chromosome .

Nam, Yoon Sung; Kim, Nam Keun; Jang, Sung Un; Lee, Sook Hwan; Yoon, Tae Ki; Cha, Kwang Yul

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Korean Journal of Obstetrics & Gynecology 2003;46(1):144-147.
Published online January 1, 2003.

A Case of Spontaneous Pregnancy in Patient with Premature Ovarian Failure Who Has a Y Chromosome .

Yoon Sung Nam, Nam Keun Kim, Sung Un Jang, Sook Hwan Lee, Tae Ki Yoon, Kwang Yul Cha

Department of Obstetrics and Gynecology, Department of Genetics, College of Medicine, Pocheon CHA University, Pocheon, Korea.

Abstract

Premature ovarian failure is a condition causing amenorrhea, hypoestrogenism, and elevated gonadotropins in women younger than 40 years. A karyotype should be performed as part of basic laboratory evaluation for all patients with premature ovarian failure and prodromal premature ovarian failure. Gonadal dysgenesis represents a wide spectrum of clinical phenotypes, gonadal structures that include the presence of at least one streak gonad, and a variety of X chromosome abnormalities and mosaicism. Development of a malignancy in a dysgenetic gonad is of major concern. The presence of a fragment of the Y chromosome is thought to be a key to the oncogenic potential of these gonads. Malignant potential is clearly not linked to the testicular determining factor itself (SRY). Failure to display SRY or a closely related sequence does not rule out the presence of the segment of the Y chromosome postulated to be associated with the development of malignancies. Pregnancy in premature ovarian failure with chromosomal abnormality is rare. Furthermore, the incidence of pregnancy in patient with Y chromosome is very rare. We have experienced a case of premature ovarian failure with chromosomal abnormality involving Y chromosome fragment. She has got pregnant spontaneously and gave birth to male baby but he was found to have the same karyotype as his mother. So we report this case with a brief review of literatures.

Key Words: Spontaneous pregnancy, Premature ovarian failure, Y chromosome

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