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Korean Journal of Obstetrics & Gynecology 2002;45(11):2035-2038.
Published online November 1, 2002.
A Case of Holoprosencephaly.
Hee Eun Ko, Il Han Lee, Ji Hoon Kim, Ey Sup Shim, Jae Whoan Koh, Yong Bong Kim
1Department of Obstetrics and Gynecology, College of Medicine, Inje University, Seoul Paik Hospital, Seoul, Korea.
2Department of Pathology, College of Medicine, Seoul National University, Seoul, Korea.
Abstract
Holoprosencephaly is a rare developmental defect due to incomplete cleavages of the prosencephalon during the third week of fetal development. It was associated with chromosomal anomalies, genetic syndrome, teratogen, or genetic disorder of non-syndromic HPE. Early antenatal detection of holoprosencephaly was done by high resolution ultrasonography. According to its severity and prognosis, it was capable of proper treatment of holoprosencephaly. We report one case of holoprosencephaly with a brief review of the literature
Key Words: Holoprosencephaly, Cebocephaly


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