Clinical Charateristics and DNA Flow Cytometry Analysis in Uterine Sarcoma.

Song, Jae Yun; Park, Hyun Tae; Soe, Dong Ju; Lee, Nak Woo; Kim, Young Tae; Lee, Kyu Wan

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Original Article

Korean Journal of Obstetrics & Gynecology 2002;45(11):1917-1923.
Published online November 1, 2002.

Clinical Charateristics and DNA Flow Cytometry Analysis in Uterine Sarcoma.

Jae Yun Song, Hyun Tae Park, Dong Ju Soe, Nak Woo Lee, Young Tae Kim, Kyu Wan Lee

Department of Obstetrics and Gynecoloy, Korea University School of Medicine, Korea.

Abstract

OBJECTIVE
To evaluate the clinicopathological characteristics and DNA flow cytometry in uterine sarcoma. METHODS: A retrospective review of twenty six patients diagnosed and treated for a uterine sarcoma in Korea university hospital from 1990 to 2000 has been performed. DNA flow cytometry was performed in eighteen patients on paraffin-embedded archival tissue from uterine sarcoma. RESULTS: Of the twenty six patients 10 cases (38.4%) were leiomyosarcoma, 7 cases (26.9%) were endometrial stromal sarcoma and 9 cases (34.6%) were malignant mixed mullerian tumor. Median survival time was 36.0 months, and 3-year survival rate were 30.8%, 55.5%, and 16.6%, respectively. Main symptoms were vaginal bleeding and abdominal distension. Using the FIGO surgical staging criteria, we found the following distribution; 7 cases (26.9%) stage I, 4 cases (15.3%) stage II, 9 cases (34.6%) stage III and 6 cases (23%) stage IV. Mean survival time were 74.7, 28.5, 27.9, and 16.6 month, respectively. Stage I and II patients had superior survival rate than Stage III and IV (p=0.0008). Fifty percent of tumors were aneuploid and in aneuploid tumors S-phase fraction rate was increased significantly (P=0.023). Patients with mitotic rate under 10 in 10 HPF had superior survival rate compaired with over 10 in 10 HPF (p=0.024). CONCLUSION: Stage and mitotic rate were suggested as most important prognostic factor in uterine sarcoma.

Key Words: Uterine sarcoma, Flow cytometry

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