A case of endometrial cancer in a young patient with polycystic ovary syndrome.

Hong, Pyo; Kim, Se Ryun; Lee, Jeong Rye; Park, Jee Hyun; Hwang, Sung Ook; Kho, Seng Kweon; Lee, Byoung Ick

Case Report

Korean Journal of Obstetrics & Gynecology 2002;45(9):1619-1623.
Published online September 1, 2002.

A case of endometrial cancer in a young patient with polycystic ovary syndrome.

Pyo Hong, Se Ryun Kim, Jeong Rye Lee, Jee Hyun Park, Sung Ook Hwang, Seng Kweon Kho, Byoung Ick Lee

Department of Obstetrics and Gynecology, Inha University Hospital, College of Medicine, Inha University, Korea.

Abstract

Endometrial cancer is a rare condition in women under 40 years of age. However, patients with anovulatory polycystic ovary syndrome are at risk of developing endometrial cancer due to unopposed and prolonged effect of estrogen on the endometrium. Polycystic ovary syndrome (PCOS) is the most common endocrinopathy in women of reproductive age resulting from insulin resistance and the compensatory hyperinsulinemia. This has adverse effects on multiple organ systems and may result in alteration in serum lipids, anovulation, abnormal uterine bleeding and infertility. In addition, PCOS may place the patients at risk for the development of type 2 diabetes, hypertension, endometrial cancer and cardiovascular disease. We report a case of endometrial cancer in a young patient with PCOS with brief review of the literatures.

Key Words: Endometrial cancer, Polycystic ovary syndrome